In the spring of 1974, Calliope Stephanides, a pupil at a girls' school in Grosse Point, Michigan, finds herself physically attracted to a classmate: a strawberry blonde, a passionate smoker with a clear talent for acting. As her feelings grow, Callie begins to suspect that she is different from the other girls. In fact, she is not a girl at all. The explanation for this strange state of affairs is a rare genetic mutation that began with a pair of lovers in a small town in Asia Minor. Carried by Callie's ancestors since the days of the declining Ottoman Empire, it has surfaced in Callie, making her a hermaphrodite. Although the gene's epic travels have come to an end, her own odyssey is only just beginning. Spanning eight decades, and one exceptionally difficult adolescence, Jeffrey Eugenides's novel is a brilliant, utterly unique tale of crossed bloodlines, the subtleties of gender and the deep, impure urges of desire. MIDDLESEX is the fulfilment of the great talent of a writer named by ‘The New Yorker’ as one of the best American novelists.